CLSI H 21-A5 PDF

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CLSI HA5 Collection, Transport, and Processing of Blood Specimens for Testing Plasma-Based Coagulation Assays and Molecular Hemostasis Assays;. CLSI HA5. Collection, Transport, and Processing of Blood Specimens for Testing Plasma-Based Coagulation Assays; Approved Guideline. HA5 does not provide general guidelines for the performance of coagulation testing. Performance guidelines for specific coagulation assays are addressed.

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Laboratories must monitor the frequency of haemolysed blood samples and investigate the source of collection to enable continuous improvement. A clear statement describing the magnitude and direction of the interference must be included.

Consensus Statement for the Management and Reporting of Haemolysed Specimens

Subscription pricing is determined by: Standards Subsctiption may be the perfect solution. Please first verify your email before subscribing to alerts. Where semi-quantitative estimates are in use, their equivalence to a conventional unit e.

Clinically relevant limits can be sourced from: Non standardisation of units.

Consensus Statement for the Management and Reporting of Haemolysed Specimens

Find articles by Ken Sikaris. The most frequently clzi causes of haemolysis of blood samples include use of inappropriately small gauge needles during phlebotomy and transfer of blood from a syringe into a vacutainer tube via a needle e.

Clin Chem Lab Med. When a POCT result shows a result e. Errors in laboratory medicine. The interference can be the result of various mechanisms including:. Ann Acad Med Singapore. Published clinical outcome studies describing performance requirements for the specific analyte. The interference with immunoassays is less frequent than with photometric assays, but is still a significant consideration; one of the most commonly affected immunoassays are the cardiac Troponin assays. Example of a Haemolysis Colour Chart which also shows haemolysis index concentration levels across different analytical platforms Courtesy Goce Dimeski, Pathology Queensland.

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Laboratories must determine and document at which H-Index level recollection of the sample is appropriate. Influence of hemolysis on routine clinical chemistry testing. Add to Alert PDF.

Need more than one copy? Appendix Example of a Haemolysis Colour Chart which also shows haemolysis index concentration levels across different analytical platforms Courtesy Goce Dimeski, Pathology Queensland. This decision should be guided by a policy developed clwi consultation with requesting clinicians. The effect of hemolysis on current troponin assays confounding preanalytical variable?

This standard is not included in any packages. Best Practice Collection Technique S1. Where multiple different analytical platforms are in use, for example 21-s5 a network of laboratories or in a large central laboratory, laboratories must ensure H-Index thresholds are appropriate for each.

The contents of articles or advertisements in The Clinical Biochemist — Reviews are not to be construed as official statements, evaluations or endorsements by the AACB, its official bodies or its agents. Haemolysis of blood samples has been documented as the most frequent pre-analytical artefact encountered by laboratories.

Best Practices in Phlebotomy.

National Center for Biotechnology InformationU. Enzymatic – release of enzymes which degrade analytes e. This standard is also available to be included in Standards Subscriptions.

Laboratories must be familiar with best practice collection processes. Haemolysis as influence and interference factor. No literary matter in The Clinical Biochemist — Reviews is to be reproduced, stored in a retrieval system or transmitted in any form by electronic or mechanical means, photocopying or recording, without permission.

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Support Center Support Center. Cut-offs at which assays are affected must be reviewed and updated when analytical platforms are changed. Areas to consider could include data mining, guidance on how to perform in-house studies and the defining of appropriate action limits. This is a useful website featuring a variety of pre-analytical issues with blood collection, sponsored by Becton Dickinson.

Spectral haemoglobin absorbs atand nm – leading to interference with alkaline phosphatase, gamma-glutamyl transferase, total and direct bilirubin. Proceed to Checkout Continue Shopping. Clssi Alert Profile lists the documents that will be monitored. Quantitative Estimation of Haemolysis S2.

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Please first log in with a verified email before subscribing to alerts. The H-index at which a clinically relevant effect is seen must be determined for each method in use.

If a laboratory decides to report affected tests, the H-Index levels used for these purposes must be documented. Requests to do so should be addressed to the Editor.

Journal List Clin Biochem Rev v. If the document is revised or amended, you will be notified by email.

Best Practices in Phlebotomy Additive – as result of greater concentrations of analytes in cells than in plasma e. The guideline provides procedures for the collection, transport, and processing of blood specimens for coagulation testing. However, these guidelines may also be considered for other sample types vlsi.