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antimicobacterianos la isioniazida rifampicina priazinamida, etambutol estreptomicina son los cinco fármacos de primera línea para el tratamiento de la. En determinadas situaciones debe añadirse un cuarto fármaco, etambutol en adultos y estreptomicina en niños, en quienes no puede Antimicobacterianos. Antibióticos beta-lactámicos y otros antibióticos de amplio espectro. Fármacos antimicobacterianos y antifúngicos. Fármacos antivirales.

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How to cite this article. Crystallographic studies on the binding of isonicotinyl-NAD adduct to wild-type and isoniazid resistant 2-trans-enoyl-ACP CoA reductase from Mycobacterium tuberculosis. Mechanism of action of diazaborines. These provide valuable opportunities for structure- or catalytic mechanism-based design of selective inhibitors as novel anti-TB drugs with improved properties.

Since the discovery of rifampin, inno one another important drug was introduced in therapeutics. The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance.

Characterization of the catalase-peroxidase gene katG and inhA locus in isoniazid-resistant and -susceptible strains of Mycobacterium tuberculosis by automated DNA sequencing: The synthesis of acid hydrazides, their derivatives and related compounds.


Michela De Luca Ferrari – Google Scholar Citations

Recent advances in new structural classes of anti-tuberculosis agents. Heterocyclic acid hydrazides and derivatives. Drug sensitivity and environmental adaptation of mycobacterial cell wall components. Receptor-independent four-dimensional quantitative structure-activity relationship analysis of a set of isoniazid derivatives. Mechanistic diversity and regulation of Type II fatty acid synthesis. En cualquier caso, el cuarto ebook pdf Oxford University Press, Broad spectrum antimicrobial biocides target the FabI component of fatty acid biosynthesis.

Chemotherapy of experimental tuberculosis – VII. Tuberculosis affects over than one billion people around the world.

This paper highlights recent approaches regarding the design of new anti-TB agents, particularly, the enoyl-ACP reductase inhibitors.

No registered users and 9 guests. However, the biochemical and functional differences between the bacterial and mammals’ antimicobactrianos acid synthetic pathway have endowed the mycobacterial enzymes with distinct properties. Inhibitors of fatty acid synthesis as antimicrobial chemotherapeutics.

The pdf printer driver and a free Converter are available for easy download. This work had as objective to obtain latent forms of pyrazinoic acid linking it to quinolones with antimycobacterial activity, through an ester bond, obtaining mutual prodrugs. Estes pesquisadores isolaram cepas de E.


So, it could act in resistant strains because is activated by esterases. To report the clinical, laboratory and pathological findings in 33 patients with DILD. The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis. Some observations on the pathogenicity of isoniazid-resistant variants of tubercle bacilli. High affinity InhA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis.

Algumas fluorquinolonas apresentam atividade antimicobacteriana, como o ciprofloxacino, antimicboacterianos e levofloxacino.

Conformational changes caused by inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis. The growing burden of tuberculosis: Isoniazid is not a lead compound for its pyridyl ring derivatives, isonicotinoyl amides, hydrazides, and hydrazones: Structural basis and mechanism of enoyl reductase inhibition by triclosan. Strategies in the search for new lead compounds or original working hypothesis. The envelope of mycobacteria.